Monday, August 20, 2012

A re-examination of the possibility of controlling the firing rate gain of neurons by balancing excitatory and inhibitory conductances

Capaday, C. (2002). A re-examination of the possibility of controlling the firing rate gain of neurons by balancing excitatory and inhibitory conductances. Exp Brain Res 143: 67-77.


"Put simply, the firing rate gain of an input to a neuron cannot be controlled by balancing excitatory and inhibitory conductances produced by other independent input pathways, or by the spatial distribution of excitation and inhibition across the neuron"

Complex 2-compartment model of alpha motorneuron. Several channels. Mainly he agrees with Holt and Koch, but does not address the same issues as my model. He shows how inhibitory feedback can change the gain, similar to how Daniel's model uses proportional inhibition to regulate the gain.

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