Monday, October 27, 2014

Working Memory Review

Circuits - Seconds

Classics on persistent activity

Fuster, J.M., Alexander, G.E. (1971) Neuron Activity Related to Short-Term Memory. Science 173(3997):652-654.

Recordings in PFC and a thalamic nucleus (nucleus medialis dorsalis). They found some neurons that have persistent activity:

Fig 2. Frequency histogroms (0.5-sec bins) of two units (A and B) in pfc during five trials with 18-second delays. Cue presentation periods marked by horizontal lines. Arrows mark the lifting of the blind and unlocking of doors which terminate the delay and immediately precede the animal's response. The two lower excerpts from the unit at left (A) represent tests of stereo tape-recorded cries of monkeys at the time of their daily feeding played back to the experimental animals by means of overhead loudspeakers.


Miller, E.K., Erickson, C.A., Desimone, R. (1996). Neural Mechanisms of Visual Working Memory in Prefrontal Cortex of the Macaque. J. Neurosci. 16(16):5154-5167.

Delayed match to sample task. Recorded in PF and IT. More than half of PF neurons show delay period activity increase. There's some interesting insights into the encoding scheme -- i.e. using projections of large numbers of neurons to represent the information, as there is a lot of variability in the type of delay activity.





Watanabe, T., Niki, H. (1985). Hippocampal Unit Activity and Delayed Response in the Monkey. Brain Research, 325: 241-254.

Recorded from a bunch of single-units in hippocampus during delay task.

TABLE I
Classification of related hippocampal units during DR
Unit type                                           n      % 
Cue-light related units                        24     8.8
Cue- and choice-light related units       41   15.0
Choice-light related units                    21    7.7
Response-related units                       51    18.8
Reward-error units                            17     6.3
Delay units                                      118   43.4
Total                                               272  100.0





Dopamine and working memory



Local depletion of dopamine in primate pfc impairs working memory: Brozoski, Brown, Rosvold, Goldman Science 1979

Dopamine-induced facilitation of NMDA receptor action is mediated by D1 receptors: Cepeda et al. Synapse 1992, Cepeda, Buchwald, Levine, PNAS 1993.

FIG 1. a, Left, schematic sequence of events in each phase of the ODR task (aligned in time with rasters and histograms shown immediately below); right, depiction of the 8 positions of the target (plus the central fixation position, 0) to be remembered for guidance of oculomotor response. b, Effect of SCH 39166 on response of neuron W54 (raster-gram above, histogram below; bin, 50 ms) for a target (position 2) in the memory field (left) and for a target (position 7) in nearly the opposite location in space (right). Top two rows, control recording showing significant but weak delay activity. Middle two rows, SCH 39166 (25 nA) produces dramatic enhancement of activity during the delay period when the target is in the memory field but produces an inhibition of activity when the target is in position 7. Bottom two rows, SKF 38393 reverses the effect of SCH 39166 and reduces delay activity to 'back-ground' level. C, cue period; D, delay period; R. response period.

So, this looks like SCH 39166 (D1 antagonist) is enhancing the "gain" of the memory field, while SKF 38393 (partial D1 agonist) reduces/eliminates the delay period activity. 

"It has been shown that D1 receptors are located preferentially on the distal dendrites and spines of pyramidal cells, but D5 receptors can also be observed on spines as well as dendritic shafts": Smiley, Levey, Ciliax, Goldman-Rakic PNAS 1994; Bergson C et al. Soc Neurosci Abstr 1994. (I think this became this paper).

"The enhancement of neuronal activity by D1 antagonists and its reversal by SKF 38393, a D1 agonist, indicates that the normal activiation of dopamine is to constrain neuronal activation during performance of a working memory task. Such an inhibitory role for dopamine is fully in accord with numeraous previous physiological studies [38]. A known mechanism of inhibition by D1 action is the attenuation of a slow inward sodium current which normally supports activation of the cell by excitatory inputs [39]." 38: Thierry, Mantz, Milla, Glowinski, J. Ann. N.Y.Acad.Sci. 1988; 39: Calabresi et al Neuroscience, 1987.

 Here's a nice Goldman-Rakic Review



"Specificaly, we argue that working memory requires rapid updating and robust maintenance as achieved by a selective gating mechanism (Braver & Cohen, 2000; Cohen, Braver, & O’Reilly, 1996; O’Reilly, Braver, & Cohen, 1999; O’Reilly & Munakata, 2000)."

Hochreiter and Schmidhuber 1997: LSTM model with gating

Striatum to GPi/SNr and from GPi/SNr to thalamus are both inhibitory. GPi/SNR is tonically active. Striatum inhibits GPi inhibits thalamus = Striatum disinhibits thalamus. 


the basal ganglia are important for initiating the storage of new memories. 

Working memory is attractor states -- in their model the recurrence for the attractor is between PFC and thalamus and back. [why not local circuitry?]. They then talk about this information relationship between thalamus and frontal, and that thalamus would need same order of neurons. However, this is avoided with the recurrent connections in frontal. [thalamus is compressed representation, potentially "blurrier", more information is stored in the recurrent PFC connections]. 

"Miller al. (1996) observed tha frontl neurons will end o be activated transintly when irrelevant stimuli are preseted wile mokeys are maintaining other task-relevant stimul." ... "frontal neurons have intrinsic maintenence capabilities." 

Possible mechanisms: Dilmore, Gutkin & Ermentrout 1999Durstewitz, Seamans, & Sejnowski, 2000b; Fellous, Wang & Lisman, 1998Gorelova & Yang, 2000; Lewis & O'Donnell, (2000) show that prefrontal neurons exhibit  bistability -- they have up and down states. Other mechanisms take advantage of the properties of the NMDA receptor. Wang 1999, bistability emerges as a result of interactions between NMDA channels and the balance of excitatory and inhibitory inputs. Durstewitz: dopamine modulates NMDA channels and inhibition to stabilize a set of active neurons.

"To summarize, in our model, active maintenance oper- ates according to the following set of principles. 1. Stimuli generally activate their corresponding frontal representations when they are presented. 2. Robust maintenance occurs only for those stimuli that trigger the intracellular maintenance switch (as a re- sult of the conjunction of external excitation from other cortical areas and Layer 4 activation resulting from basal- ganglia-mediated disinhibition of the thalamocorticalloops). 3. When other stimuli are being maintained, those representations that did not have the intracellularswitch activated will decay quickly following stimulus offset. 4. However, if nothing else is being maintained, recurrent excitation is sufficient to maintain a stimulus untilother stimuli are presented. This “default” maintenanceis important for learning, by trial and error, what it is relevant to maintain."

Striatum: 111 million neurons (Fox & Rafols, 1976)
GPi/SNR: 160 thousand neurons (Lange, Thorner & Hopf, 1976)

"An interesting possible candidate for the regions of the frontal cortex that are independently controled by the basal ganglia are distinctive anatomical structures con- sisting of interconnected groups of neurons, called stripes (Levitt, Lewis, Yoshioka, & Lund, 1993; Pucak, Levitt, Lund, & Lewis, 1996). Each stripe appears to be isolated from the immediately adjacent tissue but interconnected with other more distal stripes, forming a cluster of inter- connected stripes. Furthermore, it appears that connectivity between the PFC and the thalamus exhibits a similar, although not identical, kind of discontinuous stripelike structuring (Erickson & Lewis, 2000). Therefore, it would be plausible that each stripe or cluster of stripes constitutes a separately controlled group of neurons;" -- there could be 20K stripes or 5K stripe clusters.

"One particularly intriguing suggestion is that the convergence of inputs from other frontal areas may be arranged in a hierarchical fashion, providing a means for more anterior frontal areas (which may represent higher level, more abstract task/goal information) to appropriately contextualize more posterior areas (e.g., supplementary and primary motor areas; Gobbel, 1997). This hierarchical structure is reflected in Figure 4."

Comprehensive literature review of FC and BG: Wise, Murray, Gerfen (1996). General theories of Frontal-Basal Ganglia system:
1. Attentional Set Shifting: need FC and BG to dynamically switch between tasks
2. Working Memory: Caudate damage on working memory function (Buters & Rosvold, 1968; Divac, Rosvold & Szwaracbart, 1967; Goldamn & Rosvold, 1972).
3. Response Learning: Passingham 1993
4. Supervisory attention: Norman & Shallice, 1986. supervisory attention system controls action by modulating the operation of the contention scheduling system. 
5. Behavior-guiding rule learning: Wise et al. 1996. 

"This notion fits well with the ideas of Fuster (1989), who suggested that the frontal cortex sits at the top of a hierarchy of sensory–motor map- ping pathways, where it is responsible for bridging the longest temporal gaps. This hierarchy can continue within the frontal cortex, with more anterior areas concerned with ever longer time scales and more abstract plans and concepts (see Christoff & Gabrieli, 2000, and Koechlin, Basso, Pietrini, Panzer, & Grafman, 1999, for recent evi- dence consistent with this idea)."

"Perhaps the dominant theme of extant computational models of the basal ganglia is that they support decision making and/or action selection (e.g., Amos, 2000; Beiser & Houk, 1998; Berns & Sejnowski, 1996; Houk & Wise, 1995; Jackson & Houghton, 1995; Kropotov & Etlinger, 1999; Wickens, 1993; Wickens et al., 1995; see Beiser, Hua, & Houk, 1997, and Wickens, 1997, for recent re- views)."

Another relevant terry paper: Seamans & Sejnowski 2001





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