Connectomic reconstruction of the inner plexiform layer in the mouse retina

Helmstaedter, M., Briggman, K. L., Turaga, S.C., Jain, V., Seung, H. S., Denk, W. (2013). Connectomic reconstruction of the inner plexiform layer in the mouse retina. Nature 500

So this is Kevin's retina data, but with extensive annotations from 224 undergrads (who did the skeletons), and then an algorithm to fill the volume and link to the skeletons.

They first classify the reconstructed cells into types, mainly based on the layer-branching pattern.

They further go on to show that some cells can be classified based on the connectivity patterns. CBC5 have been seen before, and thought to contain several true classes of ganglion cells. They show that there is a connectivity feature that separates CBC5A from the rest. They show that CBC5A is a "true type" because it tiles the retina.

Finally they look at the circuitry of some of the cells.